Created by Liz Tuccillo.
Best Medicine premiered on January 4, 2026.
Distributed by FOX Entertainment Global.
Best Medicine TV Series Review
Best Medicine is a warm medical comedy-drama that follows Dr. Martin Best, a brilliant surgeon who settles into general practice in the quirky coastal town of Port Wenn.
Josh Charles gives the series its dry humor and emotional center, while the supporting cast adds plenty of personality.
Season 1 introduces Martin’s difficult personality, blood phobia and uneasy relationship with the townspeople.
His medical cases and growing connection with Louisa create a charming mix of comedy and drama.
Season 2 builds on that foundation with professional scrutiny, romantic complications and more unusual medical cases, while continuing to emphasize friendship and community.
CR Rating: 7.5/10.
Best Medicine Actors
Josh Charles as Dr. Martin Best
DOB: September 15, 1971.
Bio: American film, television and stage actor born in Baltimore, Maryland.
He began performing comedy at the age of nine and later attended the Baltimore School for the Arts, where he was a classmate of Jada Pinkett Smith and Tupac Shakur.
Role: Dr. Martin Best is a brilliant surgeon who leaves his prestigious career in Boston to become the general practitioner in Port Wenn, a small coastal village in Maine where he spent summers as a child.
Although Martin is highly skilled at diagnosing and treating patients, his blunt and often abrasive bedside manner quickly alienates many of the town’s residents.
Seasons & Episodes: S1-2 (27 eps).
Interesting facts: Charles began performing comedy when he was nine years old and later studied at the Baltimore School for the Arts.
Notable Works: The Good Wife, Sports Night, Four Brothers, In Treatment, The Power.
Abigail Spencer as Louisa Gavin
DOB: August 4, 1981.
Bio: American actress, producer and writer born in Gulf Breeze, Florida.
She began her acting career as Rebecca Tyree on the daytime soap opera All My Children before moving into primetime television.
Role: Louisa Gavin is a teacher in Port Wenn who quickly finds herself at odds with Martin Best because of his blunt and abrasive manner.
Despite their differences, she becomes one of the people closest to Martin, and their complicated relationship develops as the series progresses.
Seasons & Episodes: S1-2 (27 eps).
Interesting facts: Spencer began her professional acting career on daytime television with All My Children, for which she received a Soap Opera Digest Award for Outstanding Female Newcomer.
Notable Works: Rectify, Timeless, Mad Men, Grey’s Anatomy, Suits, Hawthorne, Oz the Great and Powerful.
Josh Segarra as Sheriff Mark Mylow
DOB: June 3, 1986.
Bio: American actor from Longwood, Florida, of Puerto Rican descent.
He graduated from New York University’s Tisch School of the Arts in 2008 with a degree in theater.
Segarra began performing at a young age and developed a career spanning television, film and theater.
Role: Sheriff Mark Mylow is the sheriff of Port Wenn and Louisa Gavin’s former fiancé.
He is an earnest and somewhat goofy member of the close-knit community who becomes caught up in the complicated relationship between Louisa and Martin Best.
Seasons & Episodes: S1-2 (27 eps).
Interesting facts: Segarra has extensive theater experience and originated the role of Emilio Estefan in On Your Feet!.
Notable Works: Arrow, Sirens, The Other Two, She-Hulk: Attorney at Law, The Electric Company.
Cree Cicchino as Elaine Denton
DOB: May 9, 2002.
Bio: American actress born and raised in Queens, New York.
She began performing as a dancer at the age of four, developing an interest in hip-hop and jazz-funk dance before turning her attention to acting.
Role: Elaine Denton is Dr. Martin Best’s administrative assistant at the Port Wenn medical practice.
She is an important member of the practice and becomes increasingly involved in Martin’s professional and personal problems.
Seasons & Episodes: S1-2 (27 eps).
Interesting facts: Cicchino began dancing at four years old and initially dreamed of becoming a professional dancer.
She later became interested in acting after her mother introduced her to a sketch-comedy group.
Notable Works: Game Shakers, Mr. Iglesias, Big Sky, The Sleepover, Turtles All the Way Down, Twinless.
Annie Potts as Aunt Sarah
DOB: October 28, 1952.
Bio: American actress known for her work in film, television, theater and voice acting.
Born in Nashville, Tennessee, she studied theater at Stephens College in Missouri before beginning a career that has spanned several decades.
Role: Aunt Sarah is Martin Best’s aunt and a local lobster woman in Port Wenn.
She is one of the people Martin has a longstanding connection with and is determined to maintain a relationship with her nephew despite his reserved and often abrasive behavior.
Seasons & Episodes: S1-2 (27 eps).
Interesting facts: Potts has received two Screen Actors Guild Award nominations for Any Day Now and an Emmy nomination for Love & War.
Notable Works: Designing Women, Young Sheldon, Ghostbusters, Toy Story, Any Day Now.
Stephen Spinella as Greg Garrison
DOB: October 11, 1956.
Bio: American stage, film and television actor born in Naples, Italy, and raised in Glendale, Arizona.
He studied drama at the University of Arizona before earning an MFA in acting from New York University’s Tisch School of the Arts.
Role: Greg Garrison is the proprietor of The Salty Breeze, one of Port Wenn’s central gathering places.
He owns the restaurant with his husband, George Brady, and frequently becomes involved in the personal dramas unfolding around Martin and the rest of the town.
Seasons & Episodes: S1-2 (14 eps).
Interesting facts: Spinella won consecutive Tony Awards in 1993 and 1994 for his performances in Angels in America.
Notable Works: Angels in America, 24, Royal Pains, City on Fire, The Education of Max Bickford.
Jason Veasey as George Brady
DOB: February 4, 1980.
Bio: New York-based actor and singer whose television work includes a variety of ensemble and supporting roles.
He has appeared in series such as Only Murders in the Building, Chicago Fire, High Maintenance, Little Voice and Flatbush Misdemeanors.
Role: George Brady is Greg Garrison’s husband and the executive chef at The Salty Breeze, the seafood restaurant they own together in Port Wenn.
George is part of the town’s close-knit community and, alongside Greg, becomes involved in the events surrounding Martin Best and the other residents.
Seasons & Episodes: S1-2 (14 eps).
Interesting facts: Veasey is also a singer and has built a television résumé that includes several ensemble and recurring roles.
Notable Works: Only Murders in the Building, Chicago Fire, High Maintenance, Flatbush Misdemeanors.
Carter Shimp as Al Large
DOB: N/A.
Bio: American actor whose screen credits include television roles in Fargo, Chicago P.D., Chicago Med, Shining Girls, Paper Girls, The Chi and Mayfair Witches.
He has worked primarily in supporting and guest roles, portraying characters across drama, crime and comedy series.
Role: Al Large is Bert Large’s son and a member of the Port Wenn community.
He develops a relationship with Elaine Denton, and their romance becomes an ongoing subplot as the series progresses.
Seasons & Episodes: S1-2 (13 eps).
Interesting facts: Shimp has appeared in several Chicago-set television productions, including Chicago P.D. and Chicago Med.
Notable Works: Fargo, Chicago P.D., Chicago Med, Paper Girls, Shining Girls, The Chi, Mayfair Witches.
Leah Janae Thomas as Amelia
DOB: N/A.
Bio: American actress and emerging performer from New York.
She has been involved in acting, voice-over work and print advertising since she was about four years old.
Before making her television debut, she appeared in commercials and other media projects.
Role: Amelia is a young member of the Port Wenn community who appears around the town alongside other local children.
She is also credited as “Intimidating Girl #2 Amelia” in the series.
Seasons & Episodes: S1-2 (11 eps).
Interesting facts: Thomas appeared in a nationwide Amazon Web Services commercial in 2022 and has worked in voice-over and advertising from a young age.
Notable Works: Amazon Web Services commercial, The Queen’s Gambit voice-over work, For Life voice-over work.
Alexandra Sica as Harley
DOB: N/A.
Bio: Alexandra Sica is an actress whose television work includes Best Medicine.
Her role as Harley has given her one of the more substantial recurring parts in the series’ supporting ensemble.
Role: Harley is one of the recurring younger characters in Port Wenn.
She frequently appears alongside Amelia and the other young members of the community.
Seasons & Episodes: S1-2 (11 eps).
Interesting facts: Sica’s Best Medicine role is her most prominent television credit currently listed in the available databases.
Notable Works: I Still Hate You.
John DiMaggio as Bert Large
DOB: September 4, 1968.
Bio: American actor, voice actor, comedian and producer born in North Plainfield, New Jersey.
He has built an extensive career across animation, live-action television, film and video games.
Role: Bert Large is a local contractor in Port Wenn and the father of Al Large.
Bert is part of the town’s established working community and becomes involved in the everyday situations surrounding Martin and the other residents.
Seasons & Episodes: S1-2 (10 eps).
Interesting facts: DiMaggio is widely recognized for voicing Bender in Futurama and Jake the Dog in Adventure Time.
He also performed stand-up comedy and had an MTV comedy show with his comedy partner.
Notable Works: Futurama, Adventure Time, Disenchantment, Better Call Saul, Mythic Quest.
Clea Lewis as Sally Mylow
DOB: July 19, 1965.
Bio: American actress born in Cleveland Heights, Ohio.
She began performing at a young age with the Cleveland Playhouse and graduated from Brown University in 1987.
Role: Sally Mylow is the town pharmacist and the mother of Sheriff Mark Mylow.
Her position gives her a natural connection to the medical side of Port Wenn, while her relationship with Mark connects her to the town’s law-enforcement storylines.
Seasons & Episodes: S1-2 (10 eps).
Interesting facts: Lewis began acting with the Cleveland Playhouse before studying at Brown University and later joining Second City in Chicago.
Notable Works: Ellen, Flying Blind, Andy Barker, P.I., Royal Pains, The Americans.
More Actors
• Didi Conn as Geneva.
• Josh Hoon Lee as Liam / Intimidating Boy #1 Liam.
• Alison Cimmet as Irma.
• Ben Lewis Doherty as Peter Cronk.
FAQ – Best Medicine TV Series
What is Best Medicine about?
Best Medicine follows Dr. Martin Best, a brilliant surgeon who leaves his career in Boston to become a general practitioner in the small fishing village of Port Wenn. His blunt personality makes adjusting to the community difficult, despite his medical abilities.
Is Best Medicine based on another TV series?
Yes. Best Medicine is an American adaptation of the British medical comedy-drama series Doc Martin.
Is Best Medicine a comedy or a medical drama?
Best Medicine combines medical drama and comedy. The series is officially described as a one-hour dramedy and blends medical cases with small-town relationships and humor.
How many seasons of Best Medicine are there?
Best Medicine currently has two seasons. Season 1 premiered in January 2026, while Season 2 began in September 2026.
Where can I watch Best Medicine?
Best Medicine airs on Fox and is available to stream through Hulu. The series is also available through Disney+ in regions where Hulu content is offered through the service.
Conclusion
Best Medicine delivers an enjoyable mix of medical comedy, small-town drama and heartfelt relationships.
With Josh Charles leading a colorful ensemble, the series balances Martin Best’s unusual personality with the warmth and humor of Port Wenn.